The largest employers in Campo include the U.S. Department of Homeland Security Border Patrol and the California Division of Juvenile Justice, Campo Juvenile Ranch.
Another feature of the area is the Pacific Southwest Railway Museum. The whistles, bells and horns of the railway of yesteryear have returned with the present activities and developments of the Pacific Southwest Railway Museum Association just north of the Campo depot. Freight operations are currently operated by the Carrizo Gorge Railway, while passenger operations are operated by the Pacific Southwest Railway Museum.