The San Diego Stock Exchange Index closed higher Friday at 118.24, up 0.47 percent from Thursday. 31 issues were down, 46 issues were up and 63 issues unchanged. Isis Pharmaceuticals Inc. (Nasdaq: ISIS) was the top dollar gainer, up $1.11 to $8.78. PICO Holdings Inc (Nasdaq: PICO) was the top dollar loser, down 97 cents to $19.63. For the complete, updated San Diego Stock Exchange Index visit sddt.com/stocks.