The San Diego Stock Exchange Index closed lower Thursday at 165.21, down 0.25 percent from Wednesday. Declining issues beat advancers 66 to 34, and 92 issues were unchanged. Mirati Therapeutics Inc. (Nasdaq: MRTX) was the top dollar gainer, up $1.10 to $21.12. Receptos Inc. (Nasdaq: RCPT) was the top dollar loser, down $1.49 to $51.63. For the complete, updated San Diego Stock Exchange Index visit sddt.com/stocks.