The San Diego Stock Exchange Index closed higher Wednesday at 121.76, up 0.26 percent from Tuesday. Declining issues beat advancers 48 to 30, and 61 issues were unchanged. Sempra Energy (New York: SRE) was the top dollar gainer, up $2.06 to $70.30. Ligand Pharmaceuticals-CL B (Nasdaq: LGND) was the top dollar loser, down 65 cents to $18.08. For the complete, updated San Diego Stock Exchange Index visit sddt.com/stocks.