The San Diego Stock Exchange Index closed lower Friday at 123.63, down 0.41 percent from Thursday. Declining issues beat advancers 47 to 34, and 58 issues were unchanged. Halozyme Therapeutics Inc. (Nasdaq: HALO) was the top dollar gainer, up $1.49 to $7.01. Qualcomm Inc. (Nasdaq: QCOM) was the top dollar loser, down $1.25 to $61.61. For the complete, updated San Diego Stock Exchange Index visit sddt.com/stocks.