The San Diego Stock Exchange Index closed higher Friday at 139.05, up 0.30 percent from Thursday. Advancing issues beat decliners 59 to 37, and 143 issues were unchanged. Neurocrine Biosciences Inc. (Nasdaq: NBIX) was the top dollar gainer, up 61 cents to $10.84. Imprimis Pharmaceuticals Inc. (Nasdaq: IMMY) was the top dollar loser, down $3.05 to $4.95. For the complete, updated San Diego Stock Exchange Index visit sddt.com/stocks.